Endocrine Abstracts

Introduction: A suspected human carcinogen and antithyroid substance, ethylenethiourea (ETU), is produced during the metabolism of ethylenebisdithiocarbamates (EBDCs). These fungicides are sprayed from above or while wearing a backpack. Ethylenethiourea (ETU), a Type II B carcinogen, and antithyroid chemicals are produced when EBDCs are broken down.Objective: The objective of conducting this research was to compare the occurrence of thyroid problems amon...

Introduction: During the perioperative period, surgical operations put patients under a great deal of physical stress. The immune system produces cytokines and other immune mediators in response to this threat. Recent studies have shown that using insulin to regulate blood glucose can reduce systemic inflammation.Objective: The objective of this research was examined how postoperative intensive insulin treatment (IIT) affects the inflammatory response in...

Background and Objectives: With menopausal transition, there is decline in estrogen concentration with potential vasomotor, physical, psychosocial, and sexual health consequences. The loss of muscle mass, strength, and function, known as sarcopenia is common in postmenopausal women. The primary objective of this study is to assess the menopausal symptoms in postmenopausal women and its association with sarcopenia.Methods: This study was conducted from Ja...

Introduction: Prior to 2015 there was no pathway for adrenal masses. An Adrenal MDT was started to discuss all the adrenal nodules (except for suspected phaechromocytoma and adrenal carcinoma) to improve the service for this cohort of patients. This audit is a review of the impact of this intervention.Methods: Data was collected between April 2016 and March 2016 for all adrenalectomies performed at East Sussex Hospitals Trust. Data was collected from the...

Introduction: Precocious puberty occurs is associated with initial increase in linear growth and acceleration of bone maturity presenting as advanced bone age with early epiphyseal fusion which ultimately results in short stature. ‘Van Wyk Grumbach Syndrome’ (VWGS) is a rare syndrome associated with incomplete isosexual precocious puberty and macroadenoma seen in cases of longstanding, untreated hypothyroidism is associated with a delayed bone age. Complete resolutio...

Opioids –Yet another Cause for Adrenal Insufficiency. Opioid prescriptions have almost doubled in the last decade in the UK. Opioid related hypogonadotropic hypogonadism is a well-recognised clinical entity. Opioid therapy as a cause of adrenal insufficiency is an under-recognised endocrinopathy with potentially lifethreatening adverse effects. We present the case of a 57 year old lady referred to the endocrine clinic with symptoms of generalised fatigue and weakness. Her...

We present here a case of diagnostic dilemma in a 34-year female presenting with Amenorrhoea. She was recently married and saw GP for infertility and history of hot flushes, melasma and migraine. Clinic history revealed primary amenorrhoea diagnosed in Brazil at age 15. Patient was told she was born without ovaries and was started on Premarin (oetrogen). She had normal female secondary sexual charcteristics, functional female genitalia and growth. On examination, she had a nor...

A 24 years old veterinary nurse presented to the cardiology outpatient clinic with palpitations, breathlessness and lethargy. There was no history of weight loss. She had a past history of bulimia. She was clinically euthyroid. ECG demonstrated sinus tachycardia with heart rate of 120 bpm. Thyroid functions test (TFT) done by GP was normal. She was initially treated with beta-blockers.She was subsequently admitted to hospital a month later with palpitati...

Estrogen, through its receptors, plays an important role in regulation of spermatogenesis. The importance of estrogen is highlighted with the reports that environmental estrogens have deleterious effects on spermatogenesis and have been associated with declining sperm counts in men. Although estrogen receptors (ERα and ERβ) have been localised in the seminiferous epithelium; their precise roles are yet unclear as in vivo estradiol treatment would signal thro...

Background: We planned this prospective cohort study in term newborn babies, with the objective to determine the incidence of vitamin D deficiency in infancy and to determine the level of vitamin D which triggers the physiological PTH axis of the body so as to differentiate truly deficient from sufficient vitamin D status.Methods: 96 participants at birth were enrolled and followed up till 9 months of age. Serum 25OHD was estimated in cord blood at birth...